Investigating the mechanism of DNA repair

FUNDING: 10 weeks (full time, 37 hrs per week, £12 per hour, £850 consumables, £500 student accommodation bursary)
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Dr. Qian Wu, Biology, Leeds

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DNA repair is critical in maintaining the integrity of our genome, and therefore is essential for cellular function. Our summer research project is tailored for undergraduate students to study the fascinating field of DNA repair research in molecular detail. The successful candidate will gain hands-on experience in protein purification and biochemical and biophysical assays used for characterising protein-protein and protein-DNA interactions, as well as structural biology using cryo-electron microscopy. Our primary research focus will be unravelling the structural mechanism of protein complexes governing DNA double-strand breaks—the most hazardous form of DNA damage in cells. Our summer research project places a strong emphasis on collaborative learning, mentorship, and the development of critical research skills. This student can contribute actively to our laboratory’s ongoing research projects, lab meetings, and journal clubs. Students may also take the opportunity to experience research culture in a broader research community in the faculty. We enthusiastically welcome students intrigued by this scientific exploration, where curiosity converges with hands-on discovery to advance our comprehension of DNA repair mechanisms. Students will be expected to present their findings orally at a research day in York in September 2024.